RT Journal Article
SR Electronic
T1 Tumorigenesis in the Brain: Location, Location, Location
JF Cancer Research
JO Cancer Res
FD American Association for Cancer Research
SP 5579
OP 5582
DO 10.1158/0008-5472.CAN-07-0760
VO 67
IS 12
A1 Gilbertson, Richard J.
A1 Gutmann, David H.
YR 2007
UL http://cancerres.aacrjournals.org/content/67/12/5579.abstract
AB Emerging evidence from numerous laboratories supports the notion that brain tumors arise from cells with stem cell/neuroglial progenitor cell properties (“cancer stem cells”). Two recent studies suggest that histologically similar tumors from different brain regions are molecularly distinct because they arise from distinct populations of site-restricted progenitor cells. These new findings imply an interaction between the cell of origin, the tumor microenvironment, and specific cancer-causing genetic changes in the evolution of central nervous system tumors. [Cancer Res 2007;67(12):5579–82] ©2007 American Association for Cancer Research.