PT  - JOURNAL ARTICLE
AU  - Lewis, Claire E.
AU  - De Palma, Michele
AU  - Naldini, Luigi
TI  - Tie2-Expressing Monocytes and Tumor Angiogenesis: Regulation by Hypoxia and Angiopoietin-2
AID  - 10.1158/0008-5472.CAN-07-1684
DP  - 2007 Sep 15
TA  - Cancer Research
PG  - 8429--8432
VI  - 67
IP  - 18
4099  - http://cancerres.aacrjournals.org/content/67/18/8429.short
4100  - http://cancerres.aacrjournals.org/content/67/18/8429.full
SO  - Cancer Res2007 Sep 15; 67
AB  - Recent findings indicate that tumor-associated macrophages are important drivers of tumor angiogenesis. Here, we review the essential role played by Tie2-expressing monocytes (TEM) in this phenomenon. TEMs are present in human blood and tumors and their elimination in various tumor models suppresses tumor angiogenesis. A ligand for Tie2, angiopoietin-2 (Ang-2), is produced by angiogenic tumor vessels and is a chemoattractant for TEMs. Hypoxia up-regulates Tie2 expression on TEMs and, together with Ang-2, down-regulates their antitumor functions. Learning more about the regulation of TEMs by the tumor microenvironment may yield new strategies to ablate the tumor vasculature. [Cancer Res 2007;67(18):8429–32] ©2007 American Association for Cancer Research.