PT  - JOURNAL ARTICLE
AU  - Chen, Fei
AU  - Castranova, Vince
TI  - Nuclear Factor-κB, an Unappreciated Tumor Suppressor
AID  - 10.1158/0008-5472.CAN-07-1576
DP  - 2007 Dec 01
TA  - Cancer Research
PG  - 11093--11098
VI  - 67
IP  - 23
4099  - http://cancerres.aacrjournals.org/content/67/23/11093.short
4100  - http://cancerres.aacrjournals.org/content/67/23/11093.full
SO  - Cancer Res2007 Dec 01; 67
AB  - The notion that nuclear factor-κB (NF-κB) is a tumor-promoting transcription factor has become a widely accepted dogma in biology. However, recent findings suggest an inhibitory role for NF-κB in carcinogenesis and tumorigenesis. Although the tumor suppressor–like effect of NF-κB remains to be rigorously established by further studies using cellular and animal models, these latest findings warrant caution with respect to blockage of NF-κB activation as a broad strategy in treating cancers. [Cancer Res 2007;67(23):11093–8] ©2007 American Association for Cancer Research.