RT Journal Article
SR Electronic
T1 Nuclear Factor-κB, an Unappreciated Tumor Suppressor
JF Cancer Research
JO Cancer Res
FD American Association for Cancer Research
SP 11093
OP 11098
DO 10.1158/0008-5472.CAN-07-1576
VO 67
IS 23
A1 Chen, Fei
A1 Castranova, Vince
YR 2007
UL http://cancerres.aacrjournals.org/content/67/23/11093.abstract
AB The notion that nuclear factor-κB (NF-κB) is a tumor-promoting transcription factor has become a widely accepted dogma in biology. However, recent findings suggest an inhibitory role for NF-κB in carcinogenesis and tumorigenesis. Although the tumor suppressor–like effect of NF-κB remains to be rigorously established by further studies using cellular and animal models, these latest findings warrant caution with respect to blockage of NF-κB activation as a broad strategy in treating cancers. [Cancer Res 2007;67(23):11093–8] ©2007 American Association for Cancer Research.