PT  - JOURNAL ARTICLE
AU  - Chng, Wee J.
AU  - Kumar, Shaji
AU  - VanWier, Scott
AU  - Ahmann, Greg
AU  - Price-Troska, Tammy
AU  - Henderson, Kim
AU  - Chung, Tae-Hoon
AU  - Kim, Seungchan
AU  - Mulligan, George
AU  - Bryant, Barbara
AU  - Carpten, John
AU  - Gertz, Morie
AU  - Rajkumar, S. Vincent
AU  - Lacy, Martha
AU  - Dispenzieri, Angela
AU  - Kyle, Robert
AU  - Greipp, Philip
AU  - Bergsagel, P. Leif
AU  - Fonseca, Rafael
TI  - Molecular Dissection of Hyperdiploid Multiple Myeloma by Gene Expression Profiling
AID  - 10.1158/0008-5472.CAN-06-4046
DP  - 2007 Apr 01
TA  - Cancer Research
PG  - 2982--2989
VI  - 67
IP  - 7
4099  - http://cancerres.aacrjournals.org/content/67/7/2982.short
4100  - http://cancerres.aacrjournals.org/content/67/7/2982.full
SO  - Cancer Res2007 Apr 01; 67
AB  - Hyperdiploid multiple myeloma (H-MM) is the most common form of myeloma. In this gene expression profiling study, we show that H-MM is defined by a protein biosynthesis signature that is primarily driven by a gene dosage mechanism as a result of trisomic chromosomes. Within H-MM, four independently validated patient clusters overexpressing nonoverlapping sets of genes that form cognate pathways/networks that have potential biological importance in multiple myeloma were identified. One prominent cluster, cluster 1, is characterized by high expression of cancer testis antigen and proliferation-associated genes. Tumors from these patients were more proliferative than tumors in other clusters (median plasma cell labeling index, 3.8; P < 0.05). Another cluster, cluster 3, is characterized by genes involved in tumor necrosis factor/nuclear factor-κB signaling and antiapoptosis. These patients have better response to bortezomib as compared with patients within other clusters (70% versus 29%; P = 0.02). Furthermore, for a group of patients generally thought to have better prognosis, a cluster of patients with short survival (cluster 1; median survival, 27 months) could be identified. This analysis illustrates the heterogeneity within H-MM and the importance of defining specific cytogenetic prognostic factors. Furthermore, the signatures that defined these clusters may provide a basis for tailoring treatment to individual patients. [Cancer Res 2007;67(7):2982–9] ©2007 American Association for Cancer Research.