RT Journal Article
SR Electronic
T1 Cell Competition and Its Possible Relation to Cancer
JF Cancer Research
JO Cancer Res
FD American Association for Cancer Research
SP 5505
OP 5507
DO 10.1158/0008-5472.CAN-07-6348
VO 68
IS 14
A1 Baker, Nicholas E.
A1 Li, Wei
YR 2008
UL http://cancerres.aacrjournals.org/content/68/14/5505.abstract
AB Cell competition can occur when cells of different genotypes share the same developing compartment, with one genotype displacing the other as a result of a proliferative advantage. Studies of cell competition in Drosophila have identified an active process of cell assassination and corpse engulfment, and also roles for Myc and the Warts/Hippo tumor suppressor pathway. Here, we discuss the possible relevance of cell competition to cancer. [Cancer Res 2008;68(14):5505–7] ©2008 American Association for Cancer Research.