RT Journal Article
SR Electronic
T1 Epitope Landscape in Breast and Colorectal Cancer
JF Cancer Research
JO Cancer Res
FD American Association for Cancer Research
SP 889
OP 892
DO 10.1158/0008-5472.CAN-07-3095
VO 68
IS 3
A1 Segal, Neil H.
A1 Parsons, D. Williams
A1 Peggs, Karl S.
A1 Velculescu, Victor
A1 Kinzler, Ken W.
A1 Vogelstein, Bert
A1 Allison, James P.
YR 2008
UL http://cancerres.aacrjournals.org/content/68/3/889.abstract
AB The finding that individual cancers contain many mutant genes not present in normal tissues has prompted considerable interest in the cancer epitope landscape. To further understand such effects, we applied in silico–based epitope prediction algorithms and high throughput post hoc analysis to identify candidate tumor antigens. Analysis of 1,152 peptides containing missense mutations previously identified in breast and colorectal cancer revealed that individual cancers accumulate on average ∼10 and ∼7 novel and unique HLA-A*0201 epitopes, respectively, including genes implicated in the neoplastic process. These data suggest that, with appropriate manipulation of the immune system, tumor cell destruction in situ may provide a polyvalent tumor vaccine without a requirement for knowledge of the targeted antigens. [Cancer Res 2008;68(3):889–92] ©2008 American Association for Cancer Research.