PT  - JOURNAL ARTICLE
AU  - Teng, Michele W.L.
AU  - Ngiow, Shin Foong
AU  - von Scheidt, Bianca
AU  - McLaughlin, Nicole
AU  - Sparwasser, Tim
AU  - Smyth, Mark J.
TI  - Conditional Regulatory T-Cell Depletion Releases Adaptive Immunity Preventing Carcinogenesis and Suppressing Established Tumor Growth
AID  - 10.1158/0008-5472.CAN-10-1681
DP  - 2010 Oct 15
TA  - Cancer Research
PG  - 7800--7809
VI  - 70
IP  - 20
4099  - http://cancerres.aacrjournals.org/content/70/20/7800.short
4100  - http://cancerres.aacrjournals.org/content/70/20/7800.full
SO  - Cancer Res2010 Oct 15; 70
AB  - Foxp3 is a central control element in the development and function of regulatory T cells (Treg), and mice expressing a diphtheria toxin (DT) receptor–enhanced green fluorescent protein fusion protein under the control of the foxp3 gene locus (DEREG mice) allow conditional and efficient depletion of Foxp3+ Treg by DT injection. Herein, we use DEREG mice and a mouse model of carcinogenesis to show that conditional and effective Treg depletion can both protect mice from carcinogenesis by innate control, yet permanently eradicate a proportion of de novo–established tumors in mice in a largely CD8+ T-cell– and IFN-γ–dependent manner. Tumors displayed a heterogeneous response to Treg depletion, and suppression of established tumors was accompanied by an increase in the tumor-infiltrating CD8+ T-cell/B-cell ratio. Tumor rejection occurred in the absence of overt autoimmunity, suggesting that effective transient Treg depletion strategies may be therapeutic in at least a proportion of spontaneous tumors developing in the host. Cancer Res; 70(20); 7800–9. ©2010 AACR.