Table 1.

Transcripts upregulated by LIN28B

Gene symbolGene nameFold changeb (vector vs. LIN28B)
Transcripts upregulated by constitutive LIN28B expression in vitroa
LGR5Leucine-rich repeat-containing G-protein–coupled receptor 57.2
PROM1Prominin 122.6
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog36.6
HMGA2High mobility group AT-hook 22.6
IGF2BP1Insulin-like growth factor 2 mRNA-binding protein 19.4
CCND2Cyclin D26.6
DKK1Dickkopf homolog 137.1
Fold changeb (tumor vs. metastases)
Transcripts upregulated in LIN28B-expressing metastases in vivoc
CHI3L1Chitinase 3-like 14.4
KLK6Kallikrein-related peptidase 64.3
TNS4Tensin 44.6
  • aSelected transcripts upregulated by constitutive LIN28B expression in colon cancer cells in vitro.

  • bFold changes indicated are the mean of 3 experimental replicates.

  • cSelected transcripts upregulated in metastases derived from primary xenograft tumors constitutively expressing LIN28B in vivo.