Table 2.

A description of SNPs in the HNF1A region with associations reported in the NHGRI GWA study catalogue

SNPr2 with rs7310409aAssociations reported in GWA cataloguePanScan-I + II
Associated traitRisk (or increaser) alleleReported P valueRef.Best tagSNP (r2)OR95% CIP
rs7310409N/AC-reactive proteinA7 × 10−17(22, 31)SNP present1.191.11–1.192 × 10−6
rs11693100.71C-reactive proteinA2 × 10−8(21)rs735396 (1.00)1.151.07–1.240.0003
rs11839100.64C-reactive proteinT1 × 10−30(20)rs2650000 (0.88)0.161.07–1.250.0001
rs11693130.64γ-Glutamyl transferaseC2 × 10−10(23)rs735396 (1.00)1.151.07–1.240.0003
rs26500000.45LDL cholesterolA2 × 10−8(24)SNP present0.161.07–1.250.0001
rs79571970.11Type 2 diabetesT2 × 10−8(26)rs7965349 (0.82)0.970.88–1.070.52
rs22598160.64Coronary heart diseaseT5 × 10−7(25)rs735396 (1.00)1.151.07–1.240.0003
rs79532490.79N-Glycan levelsG2 × 10−8(27)rs7310409 (0.89)1.191.11–1.192 × 10−6
rs7353960.64N-Glycan levelsG4 × 10−8(27)SNP present1.151.07–1.240.0003
  • aAllr2 values are derived from HapMap3 CEU data.