Table 2

Mean serum testosterone levels (ng/ml) in rats treated with various doses of s.c. Leuprolide versus surgical castration

TreatmentDay 1Day 2Day 4Day 6Day 10
Vehicle control2.11 ± 0.15a1.85 ± 0.212.01 ± 0.171.92 ± 0.211.86 ± 0.13
Surgical castration<0.1b<0.1b<0.1b<0.1b<0.1b
Leuprolide
 1.04 mg/kg1.99 ± 0.121.31 ± 0.290.29 ± 0.02bNDc0.17 ± 0.03b
 5.2 mg/kg2.19 ± 0.11.12 ± 0.14b0.21 ± 0.01b<0.1b<0.1b
 12.5 mg/kg3.16 ± 0.521.93 ± 0.50.48 ± 0.140.14 ± 0.02<0.1b
  • a Values are mean ± SE.

  • b P < 0.05 versus vehicle control.

  • c ND, not determined.