Table 4

Effect of 701 or Leuprolide alone and in combination on Dunning H prostate cancer cell density and total numbera

TreatmentH-Tumor cell density at day 63 (× 108 cells/cm3)Total no.b of H-prostate cancer cells(× 109 cells)
None (day 0)8.9 ± 0.356.96 ± 0.54
Vehiclec8.7 ± 0.2216.00 ± 2.69c
Leuprolidec4.3 ± 0.15d4.73 ± 0.07d
CEP-701c5.0 ± 0.81d8.21 ± 0.07d
Leuprolide and CEP-701c1.8 ± 0.10d1.32 ± 0.07d
  • a Values are expressed as mean ± SE.

  • b Total number cells = tumor volume × tumor cell density.

  • c Day 63.

  • d P < 0.05 compared with day 0.