Table 1

XRCC1 genotype and allele frequency among Taiwanese and North Carolinian (NC) populations of whites (W) and blacks (B)

XRCC1 PolymorphismsNC community populationTaiwanese (n = 120)Reported allele frequency (n = 12)a
Whites (n = 169)Blacks (n = 98)
Exon 6,
Codon 194
Arg/Arg150 (89%)89 (91%)67 (56%)
Arg/Trp18 (11%)9 (9%)42 (35%)
Try/Trp1 (0.5%)0 (0%)11 (8%)
 Allele frequency (Trp)0.06b,c,d0.05c,d0.27d0.25
Exon 9,
Codon 280
Arg/Arg159 (94%)94 (96%)95 (79%)
Arg/His10 (6%)4 (4%)23 (20%)
His/His0 (0%)0 (0%)2 (2%)
 Allele frequency (His)0.03c,d0.02c,d0.11d0.08
Exon 10
Codon 399
Arg/Arg65 (38%)67 (69%)63 (53%)
Arg/Gln83 (49%)27 (28%)51 (43%)
Gln/Gln21 (13%)3 (3%)6 (4%)
 Allele frequency (Gln)0.37d0.17d0.26d0.25
  • a From Shen et al. (1).

  • b Allelic distribution for codon 194, 280, and 399 genotypes in Blacks (B), Whites (W), and Taiwanese (T) sample populations were in Hardy Weinberg equilibrium.

  • c Allele frequencies for W versus B were not significantly different: codon 194, P = 0.7; codon 280, P = 0.7.

  • d Allele frequency for the following were significantly different: codon 194, W versus T, B versus T, P < 0.0001; codon 280, W versus T, B versus T, P < 0.0005; codon 399, W versus B, P < 0.0001; codon 399, W versus T, B versus T, P < 0.05.