Table 2

The association between AFB1-DNA adducts and XRCC1 polymorphisms

Nondetectable adducts (n = 51)Detectable adducts (n = 69)Crude ORa95% CI; PAdjusted ORb95% CI; P
Exon 6, codon 194
Arg/Arg25421.0c1.0c
Arg/Trp21210.60.3–1.4; 0.270.50.2–1.2; 0.12
Trp/Trp560.70.2–3.1; 0.860.70.2–2.6; 0.61
Arg/Trp + Trp/Trp26270.60.3–1.3; 0.190.60.3–1.2; 0.14
Exon 9, codon 280
Arg/Arg41541.0c1.0c
Arg/His9141.20.4–3.3; 0.911.10.4–2.9; 0.82
His/His110.80–61.5; 0.600.70–12.9; 0.84
Arg/His + His/His10151.10.4–3.1; 1.01.10.4–2.7; 0.87
Exon 10, codon 399
Arg/Arg33301.0c1.0c
Arg/Gln17342.21.0–5.1; 0.072.71.2–6.1; 0.017
Gln/Gln155.5d0.6–131; 0.216.40.7–60.8; 0.11
Arg/Gln + Gln/Gln18392.41.1–5.4; 0.032.91.3–6.4; 0.008
  • a Fisher exact OR.

  • b OR adjusted for season, calculated by logistic regression.

  • c Reference group.

  • d Test for trend χ2 = 5.1; P = 0.024.