Table 4

The association of GPA NN and NO variants and XRCC1 genotypes

GenotypesMean GPA NO VF (per 106 cells)Mean GPA NN VF (per 106 cells)
All subjectsaSmokersbNonsmokersbAll subjectsaSmokersbNonsmokersb
NLS meanSEcNLS meanSEcNLS meanSEcNLS meanSEcNLS meanSEcNLS meanSEc
Exon 6, Codon 194
Arg/Arg5513.60.94512.90.91016.92.95511.61.04511.11.11013.52.7
Arg/Trp413.13.5412.93.20410.44.0411.03.90
Trp/Trp00000
Exon 9, Codon 290
Arg/Arg5613.60.94712.90.9917.13.25611.51.04711.11.1913.33.0
Arg/His3133.9213.34.3115.09.7311.84.5211.15.3115.29.0
His/His00000
Exon 10, Codon 399
Arg/Arg3113.31.22612.61.2518.14.83110.1d1.32610.0d1.4512.14.4
Arg/Gln2213.91.41913.31.4316.16.02211.4e1.51910.6e1.6315.55.5
Gln/Gln613.52.8412.43.1214.97.9619.6d,e3.0421.0d,e3.5214.17.2
  • a Adjusted for smoking and age.

  • b For smokers or nonsmokers adjusted for age.

  • c Standard error of the mean.

  • d P < 0.01, Gln/Gln versus Arg/Arg.

  • e P < 0.05, Gln/Gln versus Arg/Gln.