Table 1

Pharmacokinetic parameters of 5-FU (100 mg/kg) after EU administration (2 mg/kg) in C57/BL6 mice

Concentration of 5-FU was determined after HPLC separation from the other radioactive species present in the extracted plasma samples as described in “Materials and Methods.” Determination of the pharmacokinetic parameters was conducted using PCNONLIN 4.2 software (ClinTrials, Lexington, KY) and standard pharmacokinetic equations.
5-FU5-FU/EU
AUC 0 → 24 (μgml/h)11 ± 172 ± 8
T1/2 (min)11 ± 142 ± 6
CLa (ml/h)89 ± 814 ± 1
Vd (ml)24 ± 311 ± 2
  • a CL, clearance.