Table 2

Effect of EU on 5-FU metabolism in liver tissue extracts

The values are expressed as percentages (±SD) of fluorine signal derived from integrals of peaks obtained from 19FNMR spectra of liver extracts from mice treated with 200 mg/kg of 5-FU alone and EU (2 mg/kg) preceding by 30 min 5-FU (200 mg/kg). Each time point represents the mean of four to seven determinations conducted on different tissue extracts. Pulse parameters are reported in “Materials and Methods.”
FNuctFUrdFUFUPAFβAL
1 h 5-FUNDaND11 ± 554 ± 1735 ± 13
2 h 5-FUNDND7 ± 435 ± 558 ± 12
1 h 5-FU+EU27 ± 119 ± 464 ± 15NDND
2 h 5-FU+EU52 ± 1015 ± 633 ± 6NDND
4 h 5-FU+EU79 ± 810 ± 411 ± 3NDND
6 h 5-FU+EU97 ± 2ND3 ± 2NDND
  • a ND, not detectable.