Table 3

Modulation of EU on 5-FU metabolism in kidney

The values are expressed as percentages (±SD) of fluorine signal derived from integrals of peaks obtained from 19FNMR spectra of kidney extracts from mice treated with 200 mg/kg of 5-FU alone and EU (2 mg/kg) preceding by 30 min 5-FU (200 mg/kg). Each time point represents the mean of four to seven determinations conducted on different tissue extracts. Pulse parameters are reported in “Materials and Methods.”
FNuctFUrdFUFUPAFβAL
1 h 5-FUNDaND11 ± 746 ± 743 ± 12
2 h 5-FUNDND14 ± 535 ± 851 ± 17
1 h 5-FU+EU29 ± 1216 ± 555 ± 18NDND
2 h 5-FU+EU56 ± 87 ± 337 ± 8NDND
4 h 5-FU+EU66 ± 8ND34 ± 7NDND
6 h 5-FU+EU80 ± 11ND20 ± 5NDND
  • a ND, not detectable.