Table 1

Comparison of calmodulin antagonism and ER-binding affinity

Calmodulin-dependent cAMP-PDE IC (μm)Rat uterine ER (RBA of E2 = 100)
Tamoxifen6.8 ± 1.15.0
Idoxifene1.4 ± 0.112.0
cis-Idoxifene1.5 ± 0.20.25