Table 5

Mean tumor PgR quickscores ± SE in E2-stimulated MCF-7 xenografts after treatment with tamoxifen, idoxifene, or cis-idoxifene, or following withdrawal of E2a

Treatment
GroupsBaseline1 week4 weeks12 weeks
E216.8 ± 0.711.0 ± 1.212.3 ± 1.9
Tamoxifen + E25.4 ± 1.76.3 ± 1.02.0 ± 0.6b
Idoxifene + E211.2 ± 1.19.5 ± 1.97.8 ± 0.7
cis-Idoxifene + E211.5 ± 2.48.4 ± 1.1
Withdrawal of E20.4 ± 0.2c1.5 ± 0.5b
  • a The numbers of tumors per group were: n = 5 at baseline and 1 week, n = 4 at week 4, and n = 5–8 after 12 weeks of treatment.

  • b P < 0.01 vs. E2 control (Mann-Whitney U test).

  • c P = 0.001 vs. E2 control (Mann-Whitney U test).