Table 3

Time to reach 1000 mg tumor for xenograft HT29 colon tumors in nu/nu mice

GEM was administered i.p. 80 mg/kg every third day for a total of three doses. MTA was administered i.p. 100 mg/kg daily for 3 days. The time to reach 1000 mg tumors was calculated in days, as described in “Materials and Methods.”
ProtocolDays ± SEDeaths
1. Sequentiala
 Control25.2 ± 2.00/10
 MTA26.0 ± 2.00/10
 GEM36.7 ± 2.00/10
 GEM followed by MTA34.5 ± 2.32/10
2. Simultaneousb
 Control12.7 ± 0.80/10
 MTA18.9 ± 0.80/10
 GEM27.8 ± 0.80/10
 Combination29.1 ± 0.80/10
3. Sequentialc
 Controls16.09 ± 1.10/18
 MTA18.60 ± 1.10/18
 GEM27.00 ± 1.10/18
 MTA followed by GEM35.00 ± 1.65/18
4. Sequential: 1-day drug-free holidayd
 Controls20.19 ± 1.10/18
 MTA22.97 ± 1.10/18
 GEM23.69 ± 1.10/18
 MTA followed by GEM40.04 ± 1.11/18
  • a Combination schedule: GEM days 0, 3, 6; MTA days 7, 8, 9.

  • b Combination schedule: MTA days 0, 1, 2; GEM days 0, 3, 6.

  • c Combination schedule: MTA days 0, 1, 2; GEM days 3, 6, 9.

  • d Combination schedule: MTA days 0, 1, 2; 1-day drug-free holiday; GEM days 4, 7, 10.