Time to reach 1000 mg tumor for xenograft HT29 colon tumors in nu/nu mice
| GEM was administered i.p. 80 mg/kg every third day for a total of three doses. MTA was administered i.p. 100 mg/kg daily for 3 days. The time to reach 1000 mg tumors was calculated in days, as described in “Materials and Methods.” | ||
|---|---|---|
| Protocol | Days ± SE | Deaths |
| 1. Sequentiala | ||
| Control | 25.2 ± 2.0 | 0/10 |
| MTA | 26.0 ± 2.0 | 0/10 |
| GEM | 36.7 ± 2.0 | 0/10 |
| GEM followed by MTA | 34.5 ± 2.3 | 2/10 |
| 2. Simultaneousb | ||
| Control | 12.7 ± 0.8 | 0/10 |
| MTA | 18.9 ± 0.8 | 0/10 |
| GEM | 27.8 ± 0.8 | 0/10 |
| Combination | 29.1 ± 0.8 | 0/10 |
| 3. Sequentialc | ||
| Controls | 16.09 ± 1.1 | 0/18 |
| MTA | 18.60 ± 1.1 | 0/18 |
| GEM | 27.00 ± 1.1 | 0/18 |
| MTA followed by GEM | 35.00 ± 1.6 | 5/18 |
| 4. Sequential: 1-day drug-free holidayd | ||
| Controls | 20.19 ± 1.1 | 0/18 |
| MTA | 22.97 ± 1.1 | 0/18 |
| GEM | 23.69 ± 1.1 | 0/18 |
| MTA followed by GEM | 40.04 ± 1.1 | 1/18 |
a Combination schedule: GEM days 0, 3, 6; MTA days 7, 8, 9.
b Combination schedule: MTA days 0, 1, 2; GEM days 0, 3, 6.
c Combination schedule: MTA days 0, 1, 2; GEM days 3, 6, 9.
d Combination schedule: MTA days 0, 1, 2; 1-day drug-free holiday; GEM days 4, 7, 10.