Table 4

Comparative effect of MTA, GEM, and sequential combination schedules on HT29 tumor growth delay

Two-way ANOVA was performed on the combined data of Protocol 3, studies A and B, as well as on the combined data of Protocol 4, studies A and B (Table 3) <$REFLINK> . Contrasts were used to compare treatments within the combined data.
Tumor growth delay
Protocol 3Protocol 4
ComparisonDays ± SEPDays ± SEP
GEM vs. Control10.91 ± 1.6<0.00013.5 ± 1.510.023
MTA vs. Control2.51 ± 1.60.122.78 ± 1.510.070
MTA → GEM vs. Control18.91 ± 1.93<0.000119.85 ± 1.53<0.0001
MTA → GEM vs. MTA16.4 ± 1.93<0.000117.07 ± 1.53<0.0001
MTA → GEM vs. GEM8.0 ± 1.930.000116.35 ± 1.53<0.0001