Table 3

Clinical, pathological, and biological characteristics of breast carcinomas according to Fhit expression

ParameterSeries 1Series 2
GeneProtein expression (IHC)aProtein expression (IHC)
AberrantNormalStrongWeakNegativeStrongWeakNegative
No. of cases9209911496047
Age >55 yr44%35%22%33%54%43%43%36%
T2 tumors67%67%44%67%90%b32%46%52%b
High mitosisNTNTNTNTNT37%55%64%b
Tumor grade III44%35%11%55%55%b19%33%33%
N+78%60%44%67%82%59%46%67%
PgR-neg.44%40%33%33%64%28%41%40%
ER-neg.44%60%33%78%55%NTNTNT
Nonductal11%25%11%22%27%12%13%19%
p53 pos.22%20%22%20%18%30%15%17%
neu pos.33%25%33%20%27%22%33%23%
  • a IHC, immunohistochemistry; NT, nontested; N+, lymphomal metastases; PgR-neg., negative progesterone receptor expression; ER-neg., negative estrogen receptor expression; pos., positive.

  • b P < 0.05 by χ2 analysis.