Table 2

CYP17 genotype by HRT use among postmenopausal women

HRT useGenotypeP
A1/A1A1/A2A2/A2
Current94 (36%)122 (34%)31 (25%)
Past54 (20%)81 (23%)33 (26%)
Never116 (44%)156 (43%)62 (49%)
Current vs. never
 ORa (95% CI)1.00.82 (0.56–1.2)0.54 (0.31–0.92)0.029
Current vs. otherb
 ORa (95% CI)1.00.81 (0.57–1.15)0.52 (0.31–0.86)0.013
  • a Adjusted for age, race/ethnicity, and weight as categorical variables.

  • b Other HRT use is a combination of never and past users.