Table 1

Numbers of mice with hyperplasia, dysplasia, and cancerous cervical epitheliuma

WeekNormalGrade
IIIIIIIV
Nontransgenic group
  61
  8
 101
 122
 14
 161
 1812
 2011
 22
 24384
Transgenic group
  61
  81
 102
 123
 1413
 161
 182
 201
 222
 2433
  • a K14-HPV16 and nontransgenic mice were implanted every 60 days with 17β-estradiol (0.250 mg per 60-day release) and fed control diet. Mice were euthanized if morbidity developed (as detected by difficulty walking) or 24 weeks later. Cervical-vaginal tissue was fixed, processed, stained (H&E), and evaluated as normal, hyperplastic (grade I), moderate dysplastic (grade II), severely dysplastic (grade III), or cancerous (grade IV) cervical epithelium.