Table 1

Detection of HCC-associated p16 methylation in plasma and serum of HCC patients

CaseAge (yr)SexCirrhosisHBsAgaTumor stagebTumor p16 methylationCirculating methylated p16 sequence (sample type)c
168M++T2++ (P)
265M++T1++ (P)
371F++T2+− (P)
462M+T2− (P)
553M++T2+− (P)
666M++T2− (P)
734M+T4++ (P)
863MT2++ (P)
976FT2++ (P)
1068M++T2++ (P)
1161M++T3+− (P)
1257M++T3++ (P)
1337M++T3− (P)
1460M++T2++ (P)
1539M++T2− (P)
1669F++T2++ (S)
1755M++T3++ (S)
1865M++T3++ (S)
1952M++T3++ (S)
2023M+T1− (S)
2130F++T2− (S)
2261FT3++ (S)
  • a HBsAg, hepatitis B surface antigen.

  • b Tumor staging was done according to Ref. 18 .

  • c P, plasma; S, serum.