Table 1

IC50s of a panel of antitumor drugs in the IGROV1, T8, and MX3 cell lines, as assessed using the sulforhodamine B method a

IGROV1 IC50 (nm)T8MX3
IC50 (nm)RfbPIC50 (nm)RfP
Topotecan12.665952<0.000517114<0.0005
9-AC2.6420779<0.000542.116<0.0005
SN-381.95344176<0.000586.244<0.0005
Camptothecin3.1513.44.3<0.00055.881.90.06
Mitoxantrone30.431911<0.000532211<0.0005
Cisplatin5477761.40.23740.70.2
5-Fluorouracil175431991.80.216681.00.9
Paclitaxel1.322.411.80.061.921.50.2
Doxorubicin88.246.60.50.278.70.90.7
  • a IC50s shown are means from at least three independent experiments.

  • b Rf, resistance factor.