Table 1

p53 mutations in patients with high-grade dysplasia in Barrett’s esophagus

CasePloidyaNucleotide changeAmino acid change
1292N388C→TLeu130Phe
1813.4N, 3.7N644–653delGTGTGGTGGTSer215Frameshift
1942N535C→THis179Tyr
2592N, ↑4Nb742C→TArg248Trp
2943.5N743G→AArg248Gln
2981.8N, 3.1N836G→AGly279Glu
333c3.4N633delTThr211Frameshift
3333.5N637C→TArg213Stp
3333.1N640delCHis214Frameshift
3332.4N, ↑4N659A→GTyr220Cys
336d3.0N577C→T; 704A→GHis193Tyr; Asn235Ser
3552.8N817C→TArg273Cys
3662N, ↑4N391–393delAACAsn131del
391e2N, 3.4N916C→TArg306Stp
4463.8N610–611delGAGlu204Frameshift
4573.0N524G→AArg175His
5322N, ↑4N944–945insTSer315Frameshift
5583.1N438G→ATrp146Stp
5923.8N742C→TArg248Trp
7073.4N818G→TArg273Leu
7682.3N818G→AArg273His
7892N388C→TLeu130Phe
7902N743G→AArg248Gln
839f3.7N, ↑4N650T→GVal217Gly
8393.6N733C→AGly245Ser
8863.1N586C→TArg196Stp
8893.7N535C→THis179Tyr
8943.2N524G→AArg175His
9102.4N743G→AArg248Gln
9162N, 3.7N743G→AArg248Gln
9472.9N712T→CCys238Arg
9802N, ↑4NIVS6+1G→TSplice donor
9941.8N492–493GC→ATLysGln164LysStp
  • a Ploidy or ploidies with p53 mutation.

  • b ↑4N, 4N fraction >6.0%.

  • c Patient 333 has four different p53 mutations, each in a unique sample.

  • d Patient 336 has two different p53 mutations in the same allele.

  • e Mutation reported previously (9) .

  • f Patient 839 has two different p53 mutations, each in a unique sample.