Table 3

Estimated OR of breast cancer development associated with number of high-risk genotypes of estrogen-metabolizing genesa

No. of high-risk genotypesNo. of cases (%)No. of controls (%)OR (95% CI)
CYP17CYP1A1COMT
No putative high-risk genotype1.00 (Ref)b
 A1/A1, A1/A2wt/wt, wt/vtH/H, H/L47 (44.3)69 (58.0)
One putative high-risk genotype1.47 (0.81–2.66)
 A2/A2wt/wt, wt/vtH/H, H/L27 (25.5)30 (25.2)
 A1/A1, A1/A2 vt/vt H/H, H/L4 (3.8)3 (2.5)
 A1/A1, A1/A2wt/wt, wt/vt L/L 14 (13.2)12 (10.1)
Two putative high-risk genotypes3.52 (1.06–12.4)
A2/A2 vt/vt H/H, H/L2 (1.9)0 (0)
A2/A2wt/wt, wt/vt L/L 7 (6.6)5 (4.2)
A1/A1A1/A2 vt/vt L/L 3 (2.8)0 (0)
All three putative high-risk genotypes
A2/A2 vt/vt L/L 2 (1.9)0 (0)
  • a P for trend = 0.006.

  • b Ref, reference group.