Table 2

Inhibition of AOM-induced ACF development in the colons of C57BL/6J mice by ONO-8711

TreatmentIntake of ONO-8711(mg/kg/day)Mice with ACFsACFs/colonaMean of ACs/focusa
Basal diet10/1016.3 ± 1.21.4 ± 0.1
Mice fed ONO-8711 during and post-AOM
 ONO-8711 (250 ppm)3710/1012.7 ± 1.0 (22)b,c1.4 ± 0.1
 ONO-8711 (500 ppm)7110/1011.3 ± 1.4 (31)c1.3 ± 0.1
 ONO-8711 (1000 ppm)14110/1010.6 ± 1.2 (35)d1.3 ± 0.0
Mice fed ONO-8711 post-AOM
 ONO-8711 (250 ppm)3510/1013.4 ± 1.71.4 ± 0.1
 ONO-8711 (500 ppm)7210/1012.5 ± 1.71.3 ± 0.1
 ONO-8711 (1000 ppm)13710/1011.3 ± 0.9 (31)d1.2 ± 0.0
  • a Data are means ± SE.

  • b Numbers in parentheses indicate percentage of inhibition compared with the basal diet group.

  • c Versus basal diet:

  • d P < 0.01.