Table 3

Inhibition of intestinal polyp development by ONO-8711 in Min micea

No. of polyps per mouseb
Polyp locationBasal dietONO-8711
Proximal small intestine2.3 ± 0.91.4 ± 0.3
Middle small intestine13.2 ± 1.78.1 ± 1.4 c
Distal small intestine42.9 ± 6.223.1 ± 2.9 d
Colon0.9 ± 0.20.8 ± 0.2
Total59.3 ± 7.333.4 ± 4.3d
  • a Mice were fed the basal diet or a diet containing 500 ppm of ONO-8711 for 7 weeks.

  • b Data are means ± SE.

  • c Versus basal diet group:

  • d P < 0.01.