Inhibition of intestinal polyp development by ONO-8711 in Min micea
| No. of polyps per mouseb | ||
|---|---|---|
| Polyp location | Basal diet | ONO-8711 |
| Proximal small intestine | 2.3 ± 0.9 | 1.4 ± 0.3 |
| Middle small intestine | 13.2 ± 1.7 | 8.1 ± 1.4 c |
| Distal small intestine | 42.9 ± 6.2 | 23.1 ± 2.9 d |
| Colon | 0.9 ± 0.2 | 0.8 ± 0.2 |
| Total | 59.3 ± 7.3 | 33.4 ± 4.3d |
a Mice were fed the basal diet or a diet containing 500 ppm of ONO-8711 for 7 weeks.
b Data are means ± SE.
c Versus basal diet group:
d P < 0.01.