Table 1

Effects of hyperoxia and hypercapnia on signal intensity in C6-pTET-VEGF tumors

TumorNormal vessel
Gas mixtureSignal intensityaPSignal intensityaP
Air767,000 ± 11,000830,000 ± 20,000
Air-CO2772,000 ± 2,5000.35b881,000 ± 15,0000.04b
Oxygen-CO2832,000 ± 12,0000.0014c976,000 ± 15,0000.002c
  • a Data are presented for two characteristic regions: a tumor with immature, nondilating functional vasculature and a normal region with mature vessel (mean ± SE; n = 4). Four images were acquired at each gas mixture (117 s/image; slice thickness, 0.5 mm; TR = 230 ms; spectral width, 25,000 Hz; field of view, 3 cm; 256 × 256 pixels; in plane resolution, 110 μm; TE = 10 ms; two averages).

  • b Student’s t test, air versus air-CO2.

  • c Student’s t test, air-CO2 versus oxygen-CO2.