Effects of hyperoxia and hypercapnia on signal intensity in C6-pTET-VEGF tumors
| Tumor | Normal vessel | |||
|---|---|---|---|---|
| Gas mixture | Signal intensitya | P | Signal intensitya | P |
| Air | 767,000 ± 11,000 | 830,000 ± 20,000 | ||
| Air-CO2 | 772,000 ± 2,500 | 0.35b | 881,000 ± 15,000 | 0.04b |
| Oxygen-CO2 | 832,000 ± 12,000 | 0.0014c | 976,000 ± 15,000 | 0.002c |
a Data are presented for two characteristic regions: a tumor with immature, nondilating functional vasculature and a normal region with mature vessel (mean ± SE; n = 4). Four images were acquired at each gas mixture (117 s/image; slice thickness, 0.5 mm; TR = 230 ms; spectral width, 25,000 Hz; field of view, 3 cm; 256 × 256 pixels; in plane resolution, 110 μm; TE = 10 ms; two averages).
b Student’s t test, air versus air-CO2.
c Student’s t test, air-CO2 versus oxygen-CO2.