Reproducibility of the assessment of VD and VF in C6-pTET VEGF tumors
| Control mice (n = 8; two slices/mouse) were imaged, and VD and VF maps were derived (t = 0). The mice were then given 5% sucrose in the drinking water without (n = 6; two slices/mouse) or with tetracyclin for the last 10 h (n = 2; two slices/mouse). No significant changes in VD or VF were observed under these conditions, in which there was no vascular damage (two-tailed unpaired t test). Some local effects were observed in VD maps at 10 h after the administration of tetracycline as shown in Fig. 1, n and p<$REFLINK> . | ||||||
|---|---|---|---|---|---|---|
| VF | VD | |||||
| Normal tissue | Tumor rim | Tumor center | Normal tissue | Tumor rim | Tumor center | |
| t =0 | 0.003 ± 0.002 | 0.006 ± 0.006 | 0.006 ± 0.003 | 0.001 ± 0.001 | 0.005 ± 0.005 | 0.002 ± 0.0015 |
| 48 h sucrose | 0.003 ± 0.0015 | 0.0075 ± 0.006 | 0.0053 ± 0.002 | 0.0024 ± 0.0016 | 0.008 ± 0.006 | 0.002 ± 0.02 |
| P | 0.89 | 0.55 | 0.47 | 0.15 | 0.26 | 0.69 |
| t = 0 | 0.004 ± 0.0008 | 0.007 ± 0.003 | 0.008 ± 0.002 | 0.001 ± 0.001 | 0.013 ± 0.005 | 0.004 ± 0.0008 |
| 10 h tetracycline | 0.001 ± 0.0015 | 0.005 ± 0.002 | 0.006 ± 0.0009 | 0.0025 ± 0.0006 | 0.015 ± 0.001 | 0.005 ± 0.0006 |
| P | 0.67 | 0.65 | 0.6 | 0.3 | 0.79 | 0.4 |