Table 2

Reproducibility of the assessment of VD and VF in C6-pTET VEGF tumors

Control mice (n = 8; two slices/mouse) were imaged, and VD and VF maps were derived (t = 0). The mice were then given 5% sucrose in the drinking water without (n = 6; two slices/mouse) or with tetracyclin for the last 10 h (n = 2; two slices/mouse). No significant changes in VD or VF were observed under these conditions, in which there was no vascular damage (two-tailed unpaired t test). Some local effects were observed in VD maps at 10 h after the administration of tetracycline as shown in Fig. 1, n and p<$REFLINK> .
VFVD
Normal tissueTumor rimTumor centerNormal tissueTumor rimTumor center
t =00.003 ± 0.0020.006 ± 0.0060.006 ± 0.0030.001 ± 0.0010.005 ± 0.0050.002 ± 0.0015
48 h sucrose0.003 ± 0.00150.0075 ± 0.0060.0053 ± 0.0020.0024 ± 0.00160.008 ± 0.0060.002 ± 0.02
P 0.890.550.470.150.260.69
t = 00.004 ± 0.00080.007 ± 0.0030.008 ± 0.0020.001 ± 0.0010.013 ± 0.0050.004 ± 0.0008
10 h tetracycline0.001 ± 0.00150.005 ± 0.0020.006 ± 0.00090.0025 ± 0.00060.015 ± 0.0010.005 ± 0.0006
P 0.670.650.60.30.790.4