Table 1

Sensitivity and specificity of FISH for discriminating negative rectal UC from non-UC control biopsies

FISH resultSensitivitySpecificity
Any abnormality
 All chromosomes1.00.9
 Chromosomes 11, 17, and 181.00.9
 Chromosome 17 only0.80.9
 Chromosome 18 only0.90.7
 Chromosome 11 only0.90.9
Abnormal arm count
 All chromosomes0.91.0
 Chromosomes 11, 17, and 181.01.0
 Chromosome 17 only0.90.9
 Chromosome 18 only0.80.9
 Chromosome 11 only0.61.0
Arm loss
 All chromosomes0.81.0
 Chromosomes 11, 17, and 180.91.0
 Chromosome 17 only0.81.0
 Chromosome 18 only0.60.9
 Chromosome 11 only0.60.8
Arm gain
 All chromosomes0.40.8
 Chromosomes 11, 17, and 180.30.8
 Chromosome 17 only0.30.9
 Chromosome 11 only0.40.9
 Chromosome 18 only0.50.7
Abnormal centromere count
 All chromosomes0.40.8
 Chromosomes 11, 17, and 180.40.8
 Chromosome 17 only0.40.8
 Chromosome 18 only0.60.8
 Chromosome 11 only0.40.9
Centromere loss
 All chromosomes0.80.8
 Chromosomes 11, 17, and 180.60.8
 Chromosome 17 only0.60.7
 Chromosome 18 only0.80.9
 Chromosome 11 only0.50.8
Centromere gain
 All chromosomes0.11.0
 Chromosomes 11, 17, and 180.50.2
 Chromosome 17 only0.30.3
 Chromosome 18 only0.50.7
 Chromosome 11 only0.40.3