HIF-1α protein expression in normal human tissues
| Tissues | Na | − | + | ++ | +++ | ++++ | Positive cells |
|---|---|---|---|---|---|---|---|
| Adrenal | 8 | 5 | 3 | Cortical cells | |||
| Fetal liver | 1 | 1 | Hepatocytes | ||||
| Kidney | 9 | 6 | 1 | 2 | Distal tubular epithelium | ||
| Pancreas | 11 | 7 | 4 | Acinar cells | |||
| Spleen | 10 | 9 | 1 | Proliferating B cells | |||
| Testis | 7 | 7 | Seminiferous tubules | ||||
| Tonsil | 3 | 1 | 1 | 1 | Proliferating B cells | ||
| Brain | 10 | 10 | |||||
| Breast | 18 | 18 | |||||
| Heart | 7 | 7 | |||||
| Large intestine | 24 | 24 | |||||
| Liver | 15 | 15 | |||||
| Lung | 10 | 10 | |||||
| Ovary | 10 | 10 | |||||
| Pituitary | 2 | 2 | |||||
| Placenta | 2 | 2 | |||||
| Prostate | 12 | 12 | |||||
| Small intestine | 1 | 1 | |||||
| Stomach | 1 | 1 | |||||
| Thyroid | 10 | 10 | |||||
| Uterus | 3 | 3 | |||||
| Total | 174 | 153 | 9 | 11 | 1 | 0 |
a N, number of cases analyzed; −, no staining; +, nuclear staining in less than 1% of cells; ++, in 1–10% of cells; +++, in 10–50%; ++++, greater than 50%.