Relationship between expression of HIF-1α and p53, bcl-2, and Ki67 in human cancersa
| Number of cases in each category are shown. | ||||||||
|---|---|---|---|---|---|---|---|---|
| p53 | bcl-2 | Ki67 LI (%) | ||||||
| − | + | − | + | <5 | 5–15 | 15–50 | >50 | |
| HIF-1α (−)a | 38 | 11 | 24 | 21 | 38 | 10 | 2 | 6 |
| HIF-1α (+/++) | 3 | 9 | 8 | 2 | 9 | 8 | 7 | 3 |
| HIF-1α (+++/++++) | 7 | 7 | 12 | 2 | 0 | 2 | 8 | 33 |
| P < 0.01b | P = 0.05b | P < 0.001c | ||||||
a −, no staining; +, nuclear staining in less than 1% of cells; ++, in 1–10% of cells; +++, in 10–50%; ++++, greater than 50%.
b Kruskal-Wallis test.
c Nonparametric Jonckhere-Terpstra test.