Table 3

Effect of T-cell enrichment: Recovery of T cells and B-CLL cells from human→mouse chimera

Patient no.UntreatedTreated with T cell enrichmentCLL ratiob
Number of miceCLL cellsT cellsNumber of miceCLL cellsT cells
%aTotal (× 104)%aTotal (× 104)%aTotal (× 104)%aTotal (× 104)
18627.6 ± 4.327.7 ± 6.21.3 ± 0.3c1.0 ± 0.1532.8 ± 5.813.2 ± 6.13.6 ± 0.71.6 ± 0.70.5
19122.015.0c11.0c7.0312.6 ± 1.35.3 ± 0.330.5 ± 0.313.3 ± 2.00.4
20134.048.02.03.0149.030.015.09.00.6
Mean ± SEd827.8 ± 3.328.6 ± 5.62.6 ± 1.22.0 ± 0.8927.9 ± 5.212.4 ± 4.113.8 ± 4.36.3 ± 2.00.5 ±0.1
(Pvalue)(NSe)(0.02)(0.02)(0.04)
  • a Percentage of total cells in peritoneal wash.

  • b Total CLL count in T-enriched mice/total CLL count in untreated.

  • c P < 0.05 in comparison with the equivalent value in the treated group.

  • d Sum of all three experiments.

  • e NS, not significant.