Table 1

Influence of 9-cis-RA on prostate carcinogenesis in Wistar-Unilever rats

Group123
Chemopreventive agentControl9-cis-RA9-cis-RA
Chemopreventive agent dose level (mg/kg diet)050100
Effective number of animals344038
No. (%) of rats with lesion
All accessory sex glands combined (dorsolateral and anterior prostate plus seminal vesicle)
 Adenocarcinoma or carcinosarcoma (+ carcinoma in situ)27 (79)13 (33)a17 (48)a
 Carcinoma in situ only3 (9)5 (13)8 (21)
Dorsolateral plus anterior prostate (clearly confined to these glands; + seminal vesicle lesions)
 Adenocarcinoma (+ carcinoma in situ)22 (65)8 (20)b7 (18)b
 Carcinoma in situ only2 (6)5 (13)6 (16)
Dorsolateral prostate region (originating from dorsolateral or anterior prostate or seminal vesicle)
 Adenocarcinoma or carcinosarcoma3 (9)4 (11)2 (5)
 Sarcoma1 (3)0 (0)0 (0)
Anterior prostate/seminal vesicle region (originating from anterior prostate or seminal vesicle)
 Adenocarcinoma4 (12)2 (5)4 (11)
Seminal vesicle only (clearly confined to this gland; + carcinoma in situ in dorsolateral/anterior prostate)
 Adenocarcinoma1 (3)3 (8)4 (11)
 Carcinoma in situ only2 (6)0 (0)4 (11)
 Sarcoma03 (8)0
  • a P < 0.01 versus group 1.

  • b P < 0.001 versus group 1.