Table 1

Frequencies of polymorphisms in CYPIA1, GSTP1, GSTM1, and GSTT1 genes in controls and patients with Barrett’s esophagus, adenocarcinoma, and squamous cell carcinoma of the esophagusa

Patients
GeneVariantControls (n = 247)Barrett’s esophagus (n = 98)Adenocarcinoma (n = 21)Squamous cell carcinoma (n = 13)
CYPIA1 (exon 7)Ile/Ile207 (84)78 (80)18 (86)8 (61)
Ile/Val37 (15)16 (16)3 (14)5 (39)
Val/Val3 (1)4 (4)0 (0)0 (0)
CYPIA1 (3′ flanking region)T/T207 (84)85 (87)14 (67)8 (61)
T/C37 (15)12 (12)7 (33)5 (39)
C/C3 (1)1 (1)0 (0)0 (0)
GSTP1a-1a Ile/Ile146 (59)29 (30)5 (24)5 (39)
GSTP1a-1b Ile/Val89 (36)58 (59)b15 (71)c6 (46)
GSTP1b-1b Val/Val12 (5)11 (11)1 (5)2 (15)
GSTM1 Deletion128 (52)43 (44)12 (57)5 (39)
GSTT1 Deletion49 (20)24 (25)4 (19)2 (15)
  • a Genetic polymorphisms were detected as described in “Materials and Methods.” Percentages are given in parentheses. The statistical significance of differences between patient and control group was assessed in 2 × 2 (GSTM1 and GSTT1) or 2 × 3 (GSTP1 and CYPIA1) contingency tables with χ2 analyses. n, number of patients or controls.

  • b P < 0.0001.

  • c P = 0.005.