Table 3

Decline of NNAL and NNAL-Gluc in the urine of rats after treatment with NNKa

Days since cessation of treatmentChronic NNK treatment, pmol/ml (% of day 15 value)Acute NNK treatment, pmol/ml
NNALNNAL-GlucNNALNNAL-Gluc
136.0 ± 11.9 (10.8)84.9 ± 31.3 (22.9)44.0 ± 22.054.1 ± 5.13
23.16 ± 1.58 (0.96)38.4 ± 8.95 (10.3)2.80 ± 0.3317.7 ± 6.0
31.07 ± 0.17 (0.33)26.6 ± 4.67 (7.2)1.23 ± 0.5813.9 ± 2.26
40.67 ± 0.32 (0.20)28.7 ± 14.0 (7.7)1.10 ± 0.579.14 ± 1.30
50.95 ± 0.01 (0.29)21.9 ± 4.57 (5.9)1.59 ± 2.756.80 ± 1.72
  • a Groups of three male F-344 rats were given NNK (2 ppm) in the drinking water for 28 days (chronic) or 2 days (acute). NNAL and NNAL-Gluc were quantified in urine for 5 days after cessation of NNK administration (see “Materials and Methods”). In the chronically treated rats, NNAL plus NNAL-Gluc in urine were also measured on day 15; levels were 371 ± 49.8 (NNAL-Gluc) and 332 ± 30.1 (NNAL) pmol/ml.