Table 4

Modulating effects of dietary curcumin on apoptosis in colon adenocarcinomas

Experimental groupApoptotic indexa (%)
Control diet5.33 ± 0.61b
0.2% curcuminc9.17 ± 1.04d
0.2% curcumine7.56 ± 0.82f
0.6% curcumine8.40 ± 0.61d
  • a Apoptotic index represents percentage of cells exhibiting apoptosis.

  • b Mean ± SE; number of adenocarcinomas examined in each group: 10.

  • c Animals were administered curcumin beginning 2 weeks before, during, and after carcinogen treatment until termination of the study (initiation and postinitiation period).

  • d Significantly different from the control diet group, P < 0.01.

  • e Animals were administered curcumin beginning 14 weeks after carcinogen treatment until termination of the study (promotion/progression period).

  • f Significantly different from the control diet group, P < 0.05.