dThd parameters in patients imaged with [C-11] dThd and [C-11] CO2.
| Patient 1, pure necrosisa | Patient 2, treated tumorb | Patient 3, active tumorc | Patient 4, low-grade tumord | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Whole-brain | Lesion | Whole-brain | Lesion | Whole-brain | Lesion | Whole-brain | Lesion | |||||
| Parameter | ||||||||||||
| Vb (ml/g) | 0.053 | 0.043 | 0.041 | 0.038 | 0.035 | 0.054 | 0.038 | 0.040 | ||||
| K1t (ml/min/g) | 0.008 | 0.059 | 0.016 | 0.047 | 0.006 | 0.106 | 0.035 | 0.030 | ||||
| KdThd (ml/min/g) | 0.007 | 0.021 | 0.006 | 0.009 | 0.0004 | 0.05 | 0.011 | 0.012 | ||||
| Lesion:Whole-brain ratios | ||||||||||||
| K1t | 7.4 | 2.9 | 17.7 | 0.9 | ||||||||
| KdThd | 3.0 | 1.5 | 125.0 | 1.1 | ||||||||
| Relative increase in flux versus transporte | 0.4 | 0.5 | 7.1 | 1.3 | ||||||||
a Neutron therapy of sinus tumor; pure radiation necrosis.
b Contrast enhancing lesion on MRI after therapy of glioblastoma; clinically stable at 3-mon follow-up.
c Active gliosarcoma.
d Untreated grade II astrocytoma.
e Relative increase in flux versus transport = lesion:whole-brain ratio for flux (KdThd) divided by lesion:whole-brain ratio for transport (K1t), i.e., ratio of ratios.