Table 4

Analyses of normal tissues from untreated and rV-CEA- and V-Wyeth-treated CEA.Tg micea

TreatmentNormal tissueHistochemical analysisbCEA expressionc
UntreatedIntestinal tractNormal+
Esophagus/stomachNormal+
KidneysNormal
LiverNormal
V-WyethIntestinal tractNormal+
Esophagus/stomachNormal+
KidneysNormalND
LiverNormalND
rV-CEAIntestinal tractNormal+
Esophagus/stomachNormal+
KidneysNormal
LiverNormalND
  • a Groups of CEA.Tg mice (two mice/group) were treated twice at 2-week intervals with 107 pfu of rV-CEA or V-Wyeth by tail scarification. Two weeks after the second treatment, mice were sacrificed, and spleens were used to generate the data summarized in Fig. 3 <$REFLINK> . Normal tissues were also removed and prepared for immunohistology. Data presented represent the results from both of the CEA.Tg mice in each group.

  • b Routine histological examinations were conducted for each specimen on H&E-stained sections.

  • c CEA expression as indicated by the presence of dark brown DAB cellular precipitate. ND, not done.