Table 3

PCR-determined hrHPV positivity and histopathological characteristics in 331 invasive anal squamous cell carcinomas according to estimated neoplastic tissue volume

No. of cancers (% hrHPV positive)No. (%) of cancers (women and men) with
WomenMenBasaloid features++/+++ keratinizationAssociated AINSmall or medium neoplastic cells
Estimated neoplastic tissue volume (× 10−3 mm3)
 <1022 (86)4 (100)6 (23)2 (8)6 (23)20 (77)
 10–2418 (94)7 (71)8 (32)8 (32)7 (28)19 (76)
 25–4939 (87)13 (69)18 (35)12 (23)16 (31)41 (79)
 50–9946 (93)13 (54)28 (47)14 (24)19 (32)47 (80)
 100–24972 (89)18 (56)45 (50)24 (27)32 (36)62 (69)
 ≥25056 (91)23 (61)40 (51)28 (35)24 (30)57 (72)
P-trenda0.810.540.020.020.820.33
  • a Mantel-Haenszel χ2-test for trend.