Table 1

Survival and mutation induction in undamaged and CENU-lex-damaged pLS76 after passage through yIG397 strain

CENU-lex (mm)Survival (%)p53 mutant frequencyMFRa
01003.3 × 10−41
(n = 16)b(16/47,821)
0.243 ± 69.8 × 10−43
(n = 6)b(6/6,087)
0.439 ± 1922 × 10−46.7
(n = 6)b(36/16,366)1
11 ± 1063 × 10−419
(n = 15)b(135/21,451)
  • a MFR, mutant frequency of CENU-lex-damaged DNA/mutant frequency of undamaged DNA.

  • b n, no. of independent transfections, i.e., no. of transfections performed with different aliquots of damaged (or undamaged) plasmid DNA.