Table 1

Associations between CYP17 genotype and breast cancer risk (Nurses’ Health Study, 1989–94).

CYP17 genotype
A1/A1 n (%)A1/A2 n (%)A2/A2 n (%)A1/A2 + A2/A2 n (%)
Controls217 (35)307 (50)94 (15)401 (65)
Cases178 (38)212 (46)73 (16)285 (62)
ORa1.00.84 (0.65–1.11)0.97 (0.67–1.41)0.87 (0.68–1.13)
ORb1.00.84 (0.63–1.12)0.91 (0.61–1.34)0.85 (0.65–1.12)
  • a Conditional logistic regression adjusted for the matching variables: age, menopausal status, postmenopausal hormone use, date of blood draw, time of blood draw, and fasting status.

  • b Conditional logistic regression adjusted for the matching variables, and age at menarche, parity, age at first birth, BMI at age 18, weight gain since age 18, benign breast disease, first-degree family history of breast cancer, and duration of postmenopausal hormone use.