Table 3

ORs and 95% CI for breast cancer risk by CYP17 genotype and menopausal status

CYP17 genotypeORAdjusted OR
A1/A1A1/A2 + A2/A2
Premenopausal
 Controls19511.0a1.0b
 Cases27370.51a (0.24–1.06)0.77b (0.33–1.82)
Postmenopausal
 Controls1803251.0c1.0d
 Cases1322250.94c (0.70–1.25)0.92d (0.68–1.23)
  • a Unconditional logistic regression adjusted for matching variables: age, date of blood draw, time of blood draw, and fasting status.

  • b Unconditional logistic regression adjusted for matching variables, and age at menarche, parity, age at first birth, BMI at age 18, weight gain since age 18, benign breast disease, and first-degree family history of breast cancer.

  • c Unconditional logistic regression adjusted for matching factors: age, postmenopausal hormone use, date of blood draw, time of blood draw, and fasting status.

  • d Unconditional logistic regression adjusted for matching variables, and age at menarche, parity, age at first birth, BMI at age 18, weight gain since age 18, age at menopause, benign breast disease, first-degree family history of breast cancer, and duration of postmenopausal hormone use.