Table 5

ORs and 95% CI for breast cancer risk and age at menarche stratified by CYP17 genotype

CasesControlsORaAdjusted ORb
Menarchec
  (A1/A1 Genotype)
 <13 yrs991041.01.0
 ≥13 yrs791120.71 (0.47–1.07)0.57 (0.36–0.90)
Menarchec
  (A1/A2 + A2/A2 genotype)
 <13 yrs1462021.01.0
 ≥13 yrs1351950.99 (0.72–1.35)1.05 (0.76–1.45)
LRT,dP = 0.07
  • a Unconditional logistic regression adjusted for matching variables: age, menopausal status, postmenopausal hormone use, date of blood draw, time of blood draw, and fasting status.

  • b Unconditional logistic regression adjusted for matching variables, and parity, age at first birth, BMI at age 18, weight gain since age 18, benign breast disease, first-degree family history of breast cancer, and duration of postmenopausal hormone use.

  • c Nine subjects with missing age at menarche removed from analysis.

  • d LRT is for the interaction between genotype and age at menarche.