Effect of NK cell depletion and platelet depletion on lung metastasis
Numbers of micrometastases and percentage of inoculated tumor cells were assessed based on counted tumor lung colonies, thickness of tissue sections, and lung volume. | ||||||
---|---|---|---|---|---|---|
NK cells | Platelets | Inoculated tumor cells | Micrometastases per | % of inoculated tumor cells | ||
mm2 | mm3 | Lung | ||||
Present | Present | 1 × 106 | 8 | 160 | 5.5 × 104 | 5.5 |
Present | Absent | 1 × 106 | 0.4 | 8 | 2.8 × 103 | 0.3 |
Absent | Present | 3 × 104 | 4 | 80 | 2.8 × 104 | 93 |
Absent | Absent | 3 × 104 | 4 | 80 | 2.8 × 104 | 93 |