Table 2

Distribution of paclitaxel in artificial binary mixture systems of the main blood fractions in the absence and presence of CrELa

Binary systemCrEL (%)Total:extracellular ratioPercentage change vs. control (%)Pb
Erythrocytes/buffercNone3.70 ± 0.061
0.500.649 ± 0.014−82.5<0.001
Erythrocytes/plasmacNone1.03 ± 0.021
0.500.664 ± 0.007−35.50.002
Platelets/plasmadNone1.33 ± 0.037
0.501.26 ± 0.024−5.260.018
  • a Paclitaxel was used at an initial concentration of 1 μg/ml and incubated in whole blood for 15 min at 37°C before fractionation and HPLC analysis. Ratio data are presented as mean values ± SD of (at least) triplicate measurements.

  • b Probability value versus control (unpaired two-sided Student’s t test).

  • c Hematocrit, ∼0.45.

  • a Platelet count, ∼750 × 109/L.